September 11th – 13th, 2019 in Würzburg, Germany: 22nd International Symposium on Signal Transduction at the Blood-Brain Barriers

Final Program

Wednesday, September 11th, 2019

Arrival to Würzburg, CCW Registration

12:00 Registration and attachment of posters (CCW Würzburg)
13:00 Introductory remarks (Lecture Hall)
Prof. Gerhard Sextl, Head of Fraunhofer ISC, Würzburg, Germany
13:05 - 13:15 Welcome by local representatives
Malgorzata Burek, University Hospital Würzburg, Germany
13:15 - 14:00

Keynote Lecture I:

Richard Daneman, University of California, San Diego, CA, USA
Regulation of the blood-brain barrier in health and disease

Session I

Brain barriers in development and homeostasis

Chairs: Britta Engelhardt (Switzerland) and Monica Giannotta (Italy)

14:00 - 14:30 Britta Engelhardt, University of Bern, Switzerland
The brain barriers: gatekeepers of CNS immune privilege
14:30 - 14:45 James Connor, Pennsylvania State University, PA, USA
Mechanisms and Regulation of Brain Iron Uptake
14:45 - 15:00 Ignazio De Trizio, University of Bari School of Medicine, Bari, Italy
Pericyte nanotubes and microtubes: are they both related to brain microvessel growth?
15:00 - 15:15 Caterina Profaci, University of California, San Diego, CA, USA
What are the molecular mechanisms of blood-brain barrier breakdown in disease?
15:15 - 15:45 Coffee Break

Session II

Pathology of the brain barriers

Chairs: Imola Wilhelm (Hungary) and Claus Pietrzik (Germany)
15:45  - 16:15 Stefan Liebner, University Hospital Frankfurt, Germany
Contribution of the blood-brain barrier in Alzheimer’s disease, mouse modelling
16:15 - 16:45 Imola Wilhelm, Biological Research Centre, Szeged, Hungary
Role of the neurovascular unit in the formation of brain metastases  
16:45 - 17:15 Serge Thal, University of Mainz, Germany
Brain glucose levels correlate with the extend of brain edema after acute brain injury
17:15 - 17:30 Arzu Temizyürek, Koc University, Istanbul, Turkey
Blood-brain barrier dynamics and anti-seizure effects of lacosamide-bound gold nanoparticles in WAG/Rij rats
17:30 - 17:45 Mariana Castro Dias, University of Bern, Switzerland
Ultrastructural 3D analysis of T-cell diapedesis across the blood-brain barrier under physiological flow
17:45 - 18:00 Luca Marchetti, University of Bern, Switzerland
Combining live cell imaging and RNAseq analysis to unveil cellular and molecular mechanisms directing T-cell diapedesis pathway across the blood-brain barrier  
18:00 - 20:00 Informal welcome reception and poster session at CCW

Thursday, September 12th, 2019

Session III

In vitro and in silico modelling and 3Rs (sponsored by Set foundation)

Chairs: Winfried Neuhaus (Austria) and Maria Deli (Hungary)

8:00 - 8:30 Winfried Neuhaus, Austrian Institute of Technology GmbH, Austria
3Rs in blood-brain barrier research: the power of in vitro models  
8:30 - 8:45 David Francisco, University of Bern, Switzerland
BBBHub: an expression datahub for brain barriers
8:45 - 9:00 Helen Onyema, Fraunhofer IMM, Germany
Establishing a stem cell-based model of the blood-brain barrier to analyze barrier permeation of nanoparticles
9:00 - 9:15 Florian Bernard Patrzynski, Université de Montréal, Canada
Primary endothelial cells from mouse brain: a useful tool to assess drug permeability to the CNS in healthy and pathological conditions
9:15 - 9:30 Gwenaëlle Le Roux, Université Paris-Saclay, France
Proof-of-Concept study of drug brain penetrability between in vivo human brain and an in vitro iPSCs-human blood-brain barrier model
9:30 - 10:00 Coffee Break
10:00 - 10:45

Keynote Lecture II:

Ethan Lippmann, Vanderbilt University, Nashville, TN, USA
Progress towards organotypic neurovascular models

Session IV

Novel approaches in engineering brain barrier

Chairs: Birger Brodin (Denmark) and Antje Appelt‐Menzel (Germany)

10:45 - 11:15 Birger Brodin, University of Copenhagen, Denmark
Stem cell modelling of the BBB with bioni010-C – a new cell line in town
11:15 - 11:30 Ana R. Santa-Maria, Biological Research Centre, Szeged, Hungary
A novel microelectronic measurement on an organ-on-a-chip device for the study of blood-brain barrier functions  
11:30 - 11:45 Anna Gerhartl, Austrian Institute of Technology GmbH, Austria
Development of flow-based hollow-fiber in-vitro models of the human blood-brain barrier for long-term studies
11:45 - 12:45 Lunch break

Session V

Molecular mechanisms regulating barrier integrity

Chairs: Malgorzata Burek (Germany) and Reiner Haseloff (Germany)

12:45 - 13:15 Anuska Andjelkovic-Zochowska, University of Michigan, MI, USA
Epigenetic regulation of BBB integrity in stroke
13:15 - 13:45 Annika Hartz, University of Kentucky, KY, USA
Restoring blood-brain barrier function to improve cognition in Alzheimer’s disease  
13:45 - 14:00 Conor Delaney, Trinity College Dublin, Ireland
Loss of CSF1R leads to systemic immune cell dysfunction, BBB breakdown and amyloid deposition at the cerebrovasculature
14:00 - 14:15 Ayal Ben-Zvi, Hebrew University of Jerusalem, Israel
BBB tight-junction function and organization revealed through super-resolution imaging
14:15 - 14:30 Muge Atis, Koc University, Istanbul, Turkey
The roles of transforming growth factor beta receptor I and dynamin on the blood-brain barrier integrity in hypertensive mice
14:30 - 15:00 Coffee Break

Session VI

Novel concepts in drug delivery across the brain barrier

Chairs: Gert Fricker (Germany) and Benjamin J. Umlauf (USA)

15:00 - 15:30 Maria Deli, Biological Research Centre, Szeged, Hungary
Nanoparticles targeting nutrient transporters at the blood-brain barrier
15:30 - 16:00 Robert Thorne, Denali Therapeutics & University of Minnesota, USA
Engineering fusion protein transport across the blood-brain barrier with a novel transferrin receptor-targeted approach
16:00 - 16:15 Carsten Hagemann, University Hospital Würzburg, Germany
Effects of Tumor Treating Fields (TTFields) on blood brain barrier (BBB) permeability in vivo
16:15 - 16:30 Benjamin J. Umlauf, University of Wisconsin-Madison, USA
Identification and development of variable lymphocyte targeting ligands for glioblastoma via exposed neural ECM
16:30 - 16:45 Mie Kristensen, University of Copenhagen, Denmark
Cargo-conjugation to tat affects its potential to facilitate brain endothelial cell adherence, uptake, and barrier permeation
18:30 - 20:00 Guided Tour through Würzburg City
20:00 Social Event at 'Residenzgaststätten Würzburg', Residenzplatz 1, 97070 Würzburg

Friday, September 13th, 2019

Session VII

Lifestyle, diet and the barrier

Chairs: Andrzej Malecki (Poland) and Daniela Virgintino (Italy)

8:30 - 9:00 Egle Solito, Queen Mary University of London, UK
Neuro-immune metabolic aging in health and disease
9:00 - 9:30 Janina Skipor, Institute of Animal Reproduction and Food Research, Olsztyn, Poland
Polyphenols and their metabolites beyond brain barriers: studies on a sheep model
9:30 - 9:45 Malgorzata Domzalska, Institute of Animal Reproduction and Food Research, Olsztyn, Poland
b-glucuronidase on both sides of choroidal blood-cerebrospinal fluid barrier in systemic inflammation in ewes
9:45 - 10:00 Reine Solange Sauer, University Hospital Würzburg, Germany
Blood nerve barrier function in painful diabetic neuropathy in rats
10:00 - 10:15 Antonio d'Amati, University of Bari School of Medicine, Bari, Italy
Annexin A1 ameliorates blood-brain barrier breakdown and neuroinflammation in metabolic diseases
10:15 - 10:30 Oxana Semyachkina-Glushkovskaya, Saratov State University, Saratov, Russian Federation
Loud music/sound opens the blood-brain barrier suggesting a readily available approach to brain drug delivery and therapy in brain diseases
10:30 - 11:00 Coffee Break

Session VIII

Role of BBB in infection (sponsored by Research Training Group 2157)

Chairs: Marco Metzger (Germany) and Brandon Kim (Germany)

11:00 - 11:30 Michal Toborek, University of Miami Miller School of Medicine, USA
Cerebrovascular pathology of HIV infection
11:30 - 11:45 Sidar Aydin, University of Bern, Switzerland
Endothelial antigen-presentation stops the migration of CD8+ T cells across the blood-brain barrier in neuroinflammation
11:45 - 12:00 Ugur Akcan, Koc University, Istanbul, Turkey
The effects of the methyl-beta-cyclodextrin and myriocin on blood-brain barrier integrity in septic rats
12:00 - 12:15 Brandon Kim, University of Würzburg, Germany
Invasion of Neisseria meningitidis into brain endothelial cells is inhibited by beta-2 adrenoceptor antagonists
12:15 - 12:30 Simon Peters, University of Würzburg, Germany
Neisseria meningitidis type IV pili trigger Ca2+-dependent lysosomal trafficking of the acid sphingomyelinase to enhance surface ceramide levels
12:30 - 12:45 Martin Palus, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic
Human BBB during tick-borne encephalitis virus infection
12:45 - 13:15 Poster prize ceremony and closing remarks
13:15 End of symposium